USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PTN6_HUMAN USC-OGP 2-DE database:  PTN6_HUMAN PTN6_HUMAN General information about the entry View entry in simple text format Entry name PTN6_HUMAN Primary accession number P29350 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Tyrosine-protein phosphatase non-receptor type 6; EC=3.1.3.48; AltName: Full=Hematopoietic cell protein-tyrosine phosphatase; AltName: Full=Protein-tyrosine phosphatase 1C; Short=PTP-1C; AltName: Full=Protein-tyrosine phosphatase SHP-1; AltName: Full=SH-PTP1;. Gene name Name=PTPN6 Synonyms=HCP, PTP1C Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0651: pI=5.91; Mw=57943 Cross-references UniProtKB/Swiss-Prot P29350; PTN6_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PTN6_HUMAN Primary accession number P29350 Secondary accession number(s) A8K306 G3V0F8 Q969V8 Q9UK67 Sequence was last modified on  December 1, 1992 (version 1) Annotations were last modified on  March 15, 2017 (version 203) Name and origin of the protein Description RecName: Full=Tyrosine-protein phosphatase non-receptor type 6; EC=3.1.3.48; AltName: Full=Hematopoietic cell protein-tyrosine phosphatase; AltName: Full=Protein-tyrosine phosphatase 1C; Short=PTP-1C; AltName: Full=Protein-tyrosine phosphatase SHP-1; AltName: Full=SH-PTP1; Gene name Name=PTPN6 Synonyms=HCP, PTP1C Encoded on Name=PTPN6; Synonyms=HCP, PTP1C Keywords 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome; Repeat; SH2 domain. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M74903; AAA35963.1; -; mRNA EMBL X62055; CAA43982.1; -; mRNA EMBL M77273; AAA36610.1; -; mRNA EMBL U15528; AAA82880.1; -; Genomic_DNA EMBL U15536; AAA82880.1; JOINED; Genomic_DNA EMBL U15535; AAA82880.1; JOINED; Genomic_DNA EMBL U15534; AAA82880.1; JOINED; Genomic_DNA EMBL U15533; AAA82880.1; JOINED; Genomic_DNA EMBL U15532; AAA82880.1; JOINED; Genomic_DNA EMBL U15531; AAA82880.1; JOINED; Genomic_DNA EMBL U15530; AAA82880.1; JOINED; Genomic_DNA EMBL U15529; AAA82880.1; JOINED; Genomic_DNA EMBL U15528; AAA82879.1; -; Genomic_DNA EMBL U15537; AAA82879.1; JOINED; Genomic_DNA EMBL U15535; AAA82879.1; JOINED; Genomic_DNA EMBL U15534; AAA82879.1; JOINED; Genomic_DNA EMBL U15533; AAA82879.1; JOINED; Genomic_DNA EMBL U15532; AAA82879.1; JOINED; Genomic_DNA EMBL U15531; AAA82879.1; JOINED; Genomic_DNA EMBL U15530; AAA82879.1; JOINED; Genomic_DNA EMBL U15529; AAA82879.1; JOINED; Genomic_DNA EMBL U47924; AAB51322.1; -; Genomic_DNA EMBL U47924; AAB51323.1; -; Genomic_DNA EMBL AF178946; AAD53317.1; -; mRNA EMBL AB079851; BAC81774.1; -; Genomic_DNA EMBL AB079851; BAC81775.1; -; Genomic_DNA EMBL AK290421; BAF83110.1; -; mRNA EMBL CH471116; EAW88703.1; -; Genomic_DNA EMBL CH471116; EAW88704.1; -; Genomic_DNA EMBL BC002523; AAH02523.1; -; mRNA EMBL BC007667; AAH07667.1; -; mRNA CCDS CCDS41744.1; -. [P29350-3]; . CCDS CCDS44820.1; -. [P29350-1]; . CCDS CCDS44821.1; -. [P29350-4]; . PIR B42031; S20825; . RefSeq NP_002822.2; NM_002831.5. [P29350-1]; . RefSeq NP_536858.1; NM_080548.4. [P29350-3]; . RefSeq NP_536859.1; NM_080549.3. [P29350-4]; . RefSeq XP_011519290.1; XM_011520988.1. [P29350-3]; . UniGene Hs.63489; -; . PDB 1FPR; X-ray; 2.50 A; A=243-526 PDB 1GWZ; X-ray; 2.50 A; A=243-541 PDB 1X6C; NMR; -; A=110-214 PDB 2B3O; X-ray; 2.80 A; A=1-532 PDB 2RMX; NMR; -; A=110-214 PDB 2YU7; NMR; -; A=110-214 PDB 3PS5; X-ray; 3.10 A; A=1-595 PDB 4GRY; X-ray; 1.70 A; A=243-528 PDB 4GRZ; X-ray; 1.37 A; A=243-528 PDB 4GS0; X-ray; 1.80 A; A/B=243-528 PDB 4HJP; X-ray; 1.40 A; A=243-528 PDB 4HJQ; X-ray; 1.80 A; A/B=243-528 PDBsum 1FPR; -; . PDBsum 1GWZ; -; . PDBsum 1X6C; -; . PDBsum 2B3O; -; . PDBsum 2RMX; -; . PDBsum 2YU7; -; . PDBsum 3PS5; -; . PDBsum 4GRY; -; . PDBsum 4GRZ; -; . PDBsum 4GS0; -; . PDBsum 4HJP; -; . PDBsum 4HJQ; -; . ProteinModelPortal P29350; -; . SMR P29350; -; . BioGrid 111742; 68; . DIP DIP-31002N; -; . IntAct P29350; 50; . MINT MINT-134053; -; . STRING 9606.ENSP00000391592; -; . BindingDB P29350; -; . ChEMBL CHEMBL3166; -; . DEPOD P29350; -; . iPTMnet P29350; -; . PhosphoSitePlus P29350; -; . BioMuta PTPN6; -; . DMDM 131469; -; . OGP P29350; -; . EPD P29350; -; . MaxQB P29350; -; . PaxDb P29350; -; . PeptideAtlas P29350; -; . PRIDE P29350; -; . DNASU 5777; -; . Ensembl ENST00000318974; ENSP00000326010; ENSG00000111679. [P29350-1]; . Ensembl ENST00000399448; ENSP00000382376; ENSG00000111679. [P29350-3]; . Ensembl ENST00000456013; ENSP00000391592; ENSG00000111679. [P29350-4]; . GeneID 5777; -; . KEGG hsa:5777; -; . UCSC uc001qsb.3; human. [P29350-1]; . CTD 5777; -; . DisGeNET 5777; -; . GeneCards PTPN6; -; . HGNC HGNC:9658; PTPN6; . HPA CAB004572; -; . HPA CAB072845; -; . HPA HPA001466; -; . MIM 176883; gene; . neXtProt NX_P29350; -; . OpenTargets ENSG00000111679; -; . PharmGKB PA34002; -; . eggNOG KOG0790; Eukaryota; . eggNOG COG5599; LUCA; . GeneTree ENSGT00870000136380; -; . HOGENOM HOG000273907; -; . HOVERGEN HBG000223; -; . InParanoid P29350; -; . KO K05697; -; . OMA QAKGEPW; -; . OrthoDB EOG091G0VZ3; -; . PhylomeDB P29350; -; . TreeFam TF351632; -; . BRENDA 3.1.3.48; 2681; . Reactome R-HSA-114604; GPVI-mediated activation cascade; . Reactome R-HSA-1433559; Regulation of KIT signaling; . Reactome R-HSA-210990; PECAM1 interactions; . Reactome R-HSA-388841; Costimulation by the CD28 family; . Reactome R-HSA-389948; PD-1 signaling; . Reactome R-HSA-391160; Signal regulatory protein (SIRP) family interactions; . Reactome R-HSA-432142; Platelet sensitization by LDL; . Reactome R-HSA-512988; Interleukin-3; 5 and GM-CSF signaling; . Reactome R-HSA-5690714; CD22 mediated BCR regulation; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-877300; Interferon gamma signaling; . Reactome R-HSA-877312; Regulation of IFNG signaling; . Reactome R-HSA-909733; Interferon alpha/beta signaling; . Reactome R-HSA-912526; Interleukin receptor SHC signaling; . Reactome R-HSA-912694; Regulation of IFNA signaling; . Reactome R-HSA-982772; Growth hormone receptor signaling; . Reactome R-HSA-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; . SignaLink P29350; -; . SIGNOR P29350; -; . ChiTaRS PTPN6; human; . EvolutionaryTrace P29350; -; . GeneWiki PTPN6; -; . GenomeRNAi 5777; -; . PMAP-CutDB P29350; -; . PRO PR:P29350; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000111679; -; . CleanEx HS_PTPN6; -; . ExpressionAtlas P29350; baseline and differential; . Genevisible P29350; HS; . GO GO:0042105; C:alpha-beta T cell receptor complex; IEA:Ensembl; . GO GO:0005911; C:cell-cell junction; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0016020; C:membrane; TAS:ProtInc; . GO GO:0005730; C:nucleolus; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:BHF-UCL; . GO GO:0035580; C:specific granule lumen; TAS:Reactome; . GO GO:1904724; C:tertiary granule lumen; TAS:Reactome; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0004725; F:protein tyrosine phosphatase activity; TAS:Reactome; . GO GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; IDA:UniProtKB; . GO GO:0033277; P:abortive mitotic cell cycle; IEA:Ensembl; . GO GO:0006915; P:apoptotic process; TAS:ProtInc; . GO GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl; . GO GO:0030154; P:cell differentiation; IDA:UniProtKB; . GO GO:0008283; P:cell proliferation; IDA:UniProtKB; . GO GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc; . GO GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl; . GO GO:0035556; P:intracellular signal transduction; IEA:Ensembl; . GO GO:0050900; P:leukocyte migration; TAS:Reactome; . GO GO:0035855; P:megakaryocyte development; IEA:Ensembl; . GO GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl; . GO GO:0050859; P:negative regulation of B cell receptor signaling pathway; IEA:Ensembl; . GO GO:0008285; P:negative regulation of cell proliferation; NAS:UniProtKB; . GO GO:0002924; P:negative regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Ensembl; . GO GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl; . GO GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL; . GO GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl; . GO GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB; . GO GO:0030168; P:platelet activation; TAS:Reactome; . GO GO:0070527; P:platelet aggregation; IEA:Ensembl; . GO GO:0030220; P:platelet formation; IEA:Ensembl; . GO GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IEA:Ensembl; . GO GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL; . GO GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IMP:BHF-UCL; . GO GO:0006470; P:protein dephosphorylation; IDA:UniProtKB; . GO GO:0045577; P:regulation of B cell differentiation; IEA:Ensembl; . GO GO:0070372; P:regulation of ERK1 and ERK2 cascade; IDA:UniProtKB; . GO GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:BHF-UCL; . GO GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl; . GO GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome; . GO GO:0031295; P:T cell costimulation; TAS:Reactome; . Gene3D 3.30.505.10; -; 2; . Gene3D 3.90.190.10; -; 1; . InterPro IPR029021; Prot-tyrosine_phosphatase-like; . InterPro IPR000242; PTPase_domain; . InterPro IPR000980; SH2; . InterPro IPR016130; Tyr_Pase_AS; . InterPro IPR003595; Tyr_Pase_cat; . InterPro IPR012152; Tyr_Pase_non-rcpt_typ-6/11; . InterPro IPR000387; TYR_PHOSPHATASE_dom; . Pfam PF00017; SH2; 2; . Pfam PF00102; Y_phosphatase; 1; . PIRSF PIRSF000929; Tyr-Ptase_nr_6; 1; . PRINTS PR00700; PRTYPHPHTASE; . PRINTS PR00401; SH2DOMAIN; . SMART SM00194; PTPc; 1; . SMART SM00404; PTPc_motif; 1; . SMART SM00252; SH2; 2; . SUPFAM SSF52799; SSF52799; 1; . SUPFAM SSF55550; SSF55550; 2; . PROSITE PS50001; SH2; 2; . PROSITE PS00383; TYR_PHOSPHATASE_1; 1; . PROSITE PS50056; TYR_PHOSPHATASE_2; 1; . PROSITE PS50055; TYR_PHOSPHATASE_PTP; 1; .

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